美国北卡罗利市和中国上海市 2019年8月16日/(GLOBE NEWSWIRE)-
致力于抗肿瘤新药开发的中美跨国制药公司徐诺药业（股票代码：XYNO）今日宣布徐诺药业研究院（XRI）通过计算机辅助药物设计成功设计了一系列强效RET激酶抑制剂。RET（“Rearranged during transfection”）是一种受体酪氨酸激酶，可激活涉及细胞增殖和存活的多个下游通路。RET融合可导致发生包括非小细胞肺癌、乳头状甲状腺癌和甲状腺髓样癌等多种肿瘤。
徐诺药业是一家专注于肿瘤药物开发的生物制药公司。徐诺药业目前的产品管线主要包括三款候选药物，艾贝司他、 XP-105 和 XP-102。公司拥有这些药物的全球独家开发、生产和商业化权益。其领先的候选药物艾贝司他正在进行治疗肾细胞癌（与培唑帕尼联用）和单药治疗非霍奇金淋巴瘤的全球关键临床试验。徐诺药业另外一款临床阶段候选药物为可进入临床2期的XP-105（BI 860585），这是一个ATP竞争性的mTORC1 / 2抑制剂，对多种实体瘤有效。徐诺药业的临床前候选药物XP-102（BI 882370）是一个泛-RAF抑制剂。
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